週次 |
日期 |
單元主題 |
第1週 |
2/27 |
Introduction (陳基旺老師) |
第2週 |
3/06 |
Enzymes I: basic binding and catalysis (孔繁璐老師) |
第3週 |
3/13 |
Enzymes II: steady-state kinetic analysis, competitive, uncompetitive inhibition (孔繁璐老師) |
第4週 |
3/20 |
Receptors: a. Binding theory and types of binding; b. Ion channels, G-protein coupled receptors (梁碧惠老師) |
第5週 |
3/27 |
Enzyme inhibitor designs: reversible enzyme inhibitors and approaches(陳基旺老師) |
第6週 |
4/03 |
溫書假 |
第7週 |
4/10 |
Enzyme inhibitor designs: irreversible enzyme inhibitors and approaches (陳基旺老師 |
第8週 |
4/17 |
Midterm Exam (陳(21%)、孔(15%_Take home)、梁(7%)) |
第9週 |
4/24 |
General concept of drug like property (忻凌偉老師) |
第10週 |
5/01 |
Lipophilicity, pKa, permeability, solubility (忻凌偉老師) |
第11週 |
5/08 |
Transporters, BBB, stability, protein binding (忻凌偉老師) |
第12週 |
5/15 |
Prodrug strategy (忻凌偉老師) |
第13週 |
5/22 |
Drug designs I: General principle: learn from history (梁碧惠老師) |
第14週 |
5/29 |
Drug designs II: a. Lead optimization: bioisosteres, conformation restriction ; b. SAR: molecular variation in homologues series and ring transformation (梁碧惠老師) |
第15週 |
6/05 |
Drug metabolism and toxicity(梁碧惠老師) |
第16週 |
6/12 |
Special topic: new strategy in drug design (陳基旺老師) |
第17週 |
6/19 |
Final Exam (陳(8%)、忻(28%)、梁(21%)) |